Faculty of Science

Synthetic biology tools for biosynthesis of small molecules

The production of bioactive small molecules in microorganisms involves orchestrating multiple genes encoding various biosynthetic enzymes.

  1. Summary of the project
  2. Eligibility criteria
  3. Readings
  4. Contact the research team leader
  5. How to apply
  6. Scholarships

Summary of the project

Fungi are prolific producers of bioactive small molecules known as secondary metabolites. These fungal secondary metabolites have been the source of medicines, including important clinical drugs such as the antibiotic penicillin and the cholesterol-lowering statins. Recent genome sequencing efforts have revealed a large number of gene clusters encoding unknown secondary metabolite biosynthetic pathways in fungi. Thus, there are immense opportunities for discovery of novel molecules from these sequenced fungal genomes  for application in medicine and agriculture.

At the same time, there is increasing interest in engineering microbes as chemical factories for sustainable production of pharmaceutical drugs, fine chemicals and fuels. This will involve constructing and engineering novel pathways in the microbial cells in a way that will maximise production, but with minimum impact on cell growth. The production of secondary metabolites in fungi involves orchestrating multiple genes encoding various biosynthetic enzymes, and often orthogonally, in response to specific environmental signals. The translated biosynthetic enzymes then come together to catalyse a series of biochemical reactions required to make the desired molecules.

Can we learn from fungi to develop better tools for engineering microbes?

By learning from fungi, we hope to hijack the genetic circuits of fungal secondary metabolite pathways as tools for engineering eukaryotic cells (yeast and filamentous fungi), for production of useful chemicals and for discovery of novel molecules from fungal genomes.

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Eligibility criteria

General UWA PhD entrance requirements can be found on the Future Students website.

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Readings

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Contact the research team leader

Once you have ensured that you meet the eligibility criteria and are ready to discuss a proposal, contact the research team leader to identify a potential supervisor.
Research team leader: Dr Yit Heng Chooi
I was awarded an ARC Discovery Early Career Researcher Awards (DECRA) in 2013. In 2015, I joined the School of Chemistry and Biochemistry at UWA to start a new research group. My research interests are on the biosynthesis of secondary metabolites in fungi and to uncover their bio-ecological roles using a combination of functional genomics, synthetic biology and chemical ecology.
 

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How to apply

After you have discussed your project with the research team leader you should be in a position to proceed to step two of the UWA application process: 'Lodge an application'.

Different procedures apply to domestic and international students.

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Scholarships

Domestic students

All domestic students may apply for Research Training Program and University Postgraduate Awards (UPA) scholarships.

The Australian Government's Endeavour Awards and Scholarships are available to Australian applicants for study in participating countries and regions.

International students

A range of scholarships are available from international organisations and governments. The full list, organised by country, is available on the Future Students website.

In addition, all international students may apply for International Research Training Program scholarships.

The Australian Government's Endeavour Awards and Scholarships are available to international applicants from participating countries and regions.

Indigenous students

Indigenous students are encouraged to apply for Indigenous Postgraduate Research Supplementary Scholarships.

Forrest Foundation scholarships

All international and Australian students who wish to study towards the degree of Doctor of Philosophy (PhD) at The University of Western Australia may apply for Forrest Scholarships.

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