Faculty of Science

Tackling carbohydrate-processing enzymes head on

The enzymes that regulate the structures of glycans are extremely important; they have been implicated in a wide variety of diseases and are thus targets for therapeutics.

  1. Summary of the project
  2. Eligibility criteria
  3. Readings
  4. Contact the research team
  5. How to apply
  6. Scholarships

Summary of the project

Our laboratory studies a wide variety of enzymes found in humans that have been implicated in cancer, Alzheimer’s disease, carbohydrate metabolism dysfunction and neurological diseases, as well as those in bacteria and microbes that are involved in antibiotic resistance and correct digestion.

Project(s) described here will be to design and synthesize new inhibitor scaffolds and various chemical tools that can be used to investigate the role these carbohydrate-processing enzymes play in the various human diseases and bacterial pathogenesis and life cycle.

The prepared compounds will be tested for their potency against the enzymes in question, and they will also be tested in vitro to determine their effectiveness at the cellular level.

Through strong international collaborations with researchers in Canada and the United Kingdom (opportunities to travel to institutions in these countries is encouraged), these compounds will also be co-crystallized with proteins of interest.

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Eligibility criteria

General UWA PhD entrance requirements can be found on the Future Students website.

Requirements specific to this project:

  • Experience with organic chemistry
  • Experience in biochemistry (desired but not essential)

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Readings

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Contact the research team leader

Once you have ensured that you meet the eligibility criteria and are ready to discuss a proposal, contact the research team leader to identify a potential supervisor.
Research team leader: Dr Keith Stubbs
I completed my undergraduate and PhD studies at UWA, followed by postdoctoral studies at Simon Fraser University in Vancouver, Canada. I currently hold an ARC Future Fellowship to further my research. My research interests are synthetic chemistry, carbohydrate chemistry and glycobiology.
 

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How to apply

Different application procedures apply to domestic and international students.

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Scholarships

Domestic students

All domestic students may apply for Research Training Program and University Postgraduate Awards (UPA) scholarships.

The Australian Government's Endeavour Awards and Scholarships are available to Australian applicants for study in participating countries and regions.

International students

A range of scholarships are available from international organisations and governments. The full list, organised by country, is available on the Future Students website.

In addition, all international students may apply for International Research Training Program scholarships.

The Australian Government's Endeavour Awards and Scholarships are available to international applicants from participating countries and regions.

Indigenous students

Indigenous students are encouraged to apply for Indigenous Postgraduate Research Supplementary Scholarships.

Forrest Foundation scholarships

All international and Australian students who wish to study towards the degree of Doctor of Philosophy (PhD) at The University of Western Australia may apply for Forrest Scholarships.

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